产品货号：
Z35053
中文名称：
MBD1抗体
英文名称：
Anti-MBD1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MBD1 Antibody |
| 指标别名 | methyl-CpG binding domain protein 1;CXXC3;PCM1;RFT;MBD1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | MBD1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human MBD1 |
| 实际分子量 | 67KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MBD1(Methyl-CpG-Binding Domain Protein 1),also known as PCM1 or CXXC3,is a protein that in humans is encoded by the MBD1 gene.Using PCR on a hybrid panel and FISH,Hendrich et al.(1999) mapped the MBD1 gene to chromosome 18q21,2.1 cM distal to MBD2.Using yeast 2-hybrid analysis,reciprocal immunoprecipitation analysis,and protein pull-down assays,Fujita et al.(2003) showed that MBD1 interacted directly with MCAF.Deletion analysis revealed that the C-terminal transcriptional repressor domain(TRD) of MBD1 interacted with a conserved C-terminal domain of MCAF.Reporter gene assays showed that MCAF increased the repressive function of the isolated TRD of MBD1 against SP1.Chromatin immunoprecipitation analysis revealed that MBD1 linked MCAF to methylated promoters.Uchimura et al.(2006) found that MBD1 was multiply sumoylated in HeLa cells.Sumoylation did not alter the intracellular localization of MBD1 at nuclear foci in C-33A human cervical cancer cells. |
| Uniprot ID | Q9UIS9 |
| 推荐稀释比 | Western blot (WB) 1:400～800 Immunohistochemistry in paraffin section (IHC) 1:20～100 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 |
相关搜索：MBD1抗体，MBD1单抗，Anti-MBD1 Antibody